Background: The level of NT-pro-BNP is known to be a strong predictor of mortality among patients with coronayr artery disease (CAD). However, it remains elusive whether it can be a prognostic marker in CAD patients with preserved LV systolic function. We investigated the association of preprocedural NT-pro-BNP level and clinical outcomes in CAD patients with preserved left ventricle(LV) systolic function after PCI Methods: A total of 3,098 patients (mean age = 62.23 짹 10.69 yrs; male = 1099 (64.5%) who underwent PCI with CAD was analyzed retrospectively in catholic registry study(Co-ACT registry). NT-pro-BNP was measured on admission prior to PCI. We compared MACE incidence between 4 groups divided by the 25% percentile level of NT-pro-BNP at 2 years after index PCI. Results: On multivariate analysis, the patients with highest quartile of NT-pro BNP was significantly associated with increased risk of death(p=0.012, adjusted odds ratio, 2.950(95% CI, 1.271-6.848)), cardiac death(p=0.008, adjusted odds ratio, 3.399(95% CI, 1.368-8.445)) and total MACE (death from any casue, MI, stroke) (p=0.036, adjusted odds ratio, 1.929(95% CI, 1.043-3.566)) compared with those with lowest quartile. Conclusions: Preprocedural NT-pro-BNP levels are associated with long-term clinical outcomes after PCI in CAD with preserved LV systolic function.