Background; Fractional flow reserve (FFR) is a gold standard to detect the ischemia-causing coronary stenosis. However, this requires invasive procedure and expensive devices. CT-derived computed fractional flow reserve (FFRCT) is a novel non-invasive technology to provide the FFR without any modification of CCTA protocols or medications. We performed this study to evaluate the feasibility of treatment planning using virtual coronary stenting and FFRCT Methods; Twenty one patients (22 lesions) with available CCTA and FFR before and after stenting were consecutively enrolledfrom 2 centers. FFRCT was assessed by core laboratory scientists blinded to patient, angiographic, and FFR data. Virtual coronary intervention was performed with the information of stent size used in each patient (Figure). Results; Minimum lumen diameter and reference diameter of target lesions were 0.9짹0.4 mm and 2.9짹0.4mm, respectively. Before intervention, invasive FFR was 0.68짹0.13 and non-invasive FFRCT was 0.69짹0.13. FFR after stenting and FFRCT after virtual intervention was 0.88짹0.05 and 0.85짹0.05, respectively. There was a good correlation between the 2 measurements (r=0.52, p=0.01) and the mean differences between post-intervention FFRCT and FFR were 0.028 (95% limit of agreement; -0.10 to 0.16) by a Blant-Altman analysis. Diagnostic accuracy of FFRCT to predict the residual ischemia (FFR <0.8) after stenting was 91% (sensitivity 100%, specificity 90%). Conclusions; FFRCT after virtual coronary intervention matched well with invasively measured post-stenting FFR. These results suggest that the treatment planning using non-invasive FFRCT and virtual intervention is feasible before the invasive procedures.