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Elevated B-Type Natriuretic Peptide (BNP) levels at admission are the independent predictor of cardiac arrhythmia following intracerebral hemorrhage (ICH)
강남병원 심장내과¹ 울산대학교 서울아산병원 심장내과²
박재홍, 이승재¹ 김유리²
Background and Objectives: Previous reports showed that BNP was a strong prognostic indicator for cardiac outcome in various clinical settings. We studied whether BNP levels at admission independently predicted cardiac events, especially cardiac arrhythmia, in patients with ICH. Method: We prospectively enrolled 101 patients with intracerebral hemorrhage admitted from January 2009 to May 2011 and obtained complete data from 77 patients. All patients were closely monitored at intensive care unit and underwent neurosurgery. Biochemical tests and clinical data were recorded at admission and other electrocardiography, holter monitoring, and echocardiographic data were analyzed in all patients during follow-up periods. We divided patients into Group I and Group II: Group I ( patients with cardiac events: 20 patients, mean age : 56.75± 15.26 years olds, 10males), group II ( patients without cardiac events: 57 patients, mean age: 70.65± 11.06 years olds, 29males). Result: During the periods following intracerebral hemorrhage, twenty patients had 25 combined cardiac events including ischemic events (cardiac death 6 patient, myocardial infarction 2 patients), ventricular tachycardia (2 patients), paroxysmal atrial fibrillation (16 patients), and paroxysmal supraventricular tachycardia (1 patient). BNP levels were significantly higher among patients who experienced cardiac events than in those who did not (657.54±1022.59 vs. 168.53±175.03 pg/mL, p=0.046). The left ventricular ejection fraction(LVEF) and glomerular filteration rate(GFR) using Modification of Diet in Renal Diseases were lower in Group I than Group II. The univariable predictors of cardiac events were BNP levels, LVEF, and GFR and BNP level was the only independent predictor on multivariate analysis after adjustment for other continuous variables(odds ratio: 1.003, 95% confidence interval: 1.000 to 1.005, p=0.038). Receiver operating characteristic curves demonstrated BNP levels as predictors of cardiac events with areas under the curve of 0.747. A BNP cut-off value above 156.9 pg/ml demonstrated high sensitivity (70%) and specificity (66.7%) for what???. BNP levels at admission was significantly associated with the occurrence of a cardiac event (odds ratio: 1.003, 95% confidence interval: 1.001 to 1.005, p=0.014). Conclusion: There was a significant association between elevated BNP levels at admission and the occurrence of cardiac events in patients with ICH. Elevated BNP levels can be used to predict cardiac events in patients admitted for ICH.


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