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Left Atrial Function Assessed By Doppler Echocardiography Rather than Left Atrial Volume Predicts Recurrence in Patients with Paroxysmal Atrial Fibrillation
연세대학교 강남세브란스병원 심장내과
정혜문, 윤지현, 최의영, 김종윤, 민필기, 윤영원, 이병권, 홍범기, 권혁문, 임세중
BACKGROUND: Paroxysmal atrial fibrillation (AF) (PaAF) has ariable proression after sinus conversion. We investigated predictors of recurrence in patients with PaAF. METHODS: The study population included 228 PaAF patients (131 men, age 64±14 years) who underwent transthoracic echocardiography immediately after sinus conversion at initial AF diagnosis. We followed study patients for AF recurrence. RESULTS: Among 228 patients, AF recurrence was demonstrated in 45 patients (20%, age 68±13 years) after sinus conversion. Recurrence group had larger left atrial (LA) volume index (LAVI, 32±12 vs. 25±10 ml/m2, P<0.001) and E/e' (14±7 vs. 12±5, P=0.012), while early diastolic mitral annular velocity (e’, 5±2 vs. 6±3 cm/s, P=0.021) and late diastolic mitral annular velocity (A’, 7±3 vs. 9±2 cm/s, P<0.001) were significantly lower. In multivariate Cox regression analysis detecting independent predictors of PaAF recurrence, lower A’ (HR 0.620, 95% CI 0.458-0.839, P=0.002) were independently significant predictors of AF recurrence. CONCLUSIONS: Late diastolic mitral annular velocity (A’) which indicates LA systolic function after sinus conversion was the independent predictor of PaAF recurrence, whereas LA volume was not. LA function may be more important than LA volume in predicting recurrence particularly in patients with PaAF.

Cox Multiple Regression Analysis for Predictors of PAF recurrence

 

 Hazard ratio (95% confidence interval)

P value

Age, y

1.008 (0.961-1.057)

0.750

Sex

0.648 (0.221-1.900)

0.429

Hypertension

1.278 (0.510-3.205)

0.601

DM

0.711 (0.182-2.783)

0.624

Cerebrovascular accident

0.521 (0.177-1.536)

0.237

Smoking

0.689 (0.240-1.977)

0.488

Antiarrhythmic drugs

0.725 (0.288-1.828)

0.496

Echocardiographic parameters

 

 

LVMI, g/m2

1.001 (0.983-1.019)

0.945

LAVI, ml/m2

1.014 (0.963-1.068)

0.592

E, cm/s

1.003 (0.970-1.038)

0.840

A, cm/s

1.004 (0.976-1.033)

0.780

e’, cm/s

0.976 (0.638-1.395)

0.894

A’, cm/s

0.620 (0.458-0.839)

0.002

S’, cm/s

1.365 (0.950-1.960)

0.092

E/e’

1.007 (0.867-1.169)

0.927



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