BACKGROUND: It is well known that glycoalbumin is independent risk factor of atherosclerosis in patients with Diabetes mellitus(DM). The aim of this study was to investigate the value of glycoalbumin for predicting multivessel coronary artery disease(CAD). METHODS: The study population included 326 patients (210 men, age 64짹11 years) who underwent coronary angiography for suspected CAD. We devided patients into three groups based on absence (normal, n=71) or presence (1 vessel disease, n=69 and multivessel disease, n=186) of documented CAD at coronary angiography. CAD was defined as > 50% luminal narrowing of at least one major epicardial coronary artery. RESULTS: Multivessel group was older (66짹10 vs. 61짹10, p<0.001) and had more male patients (76% vs.41%, p<0.001). Fasting blood glucose (FBG) (117짹41 vs. 105짹26, p=0.038), HbA1c (6.8짹1.4 vs. 6.1짹1.0, p<0.001), glycoalbumin (18.6짹17.5 vs. 13.4짹3.1, p=0.012) and MS score (2.7짹1.2 vs. 2.3짹1.2, p=0.005) were higher in multivessel group than normal group. HDL (37짹10 vs. 45짹16, p<0.001) and eGFR (77짹23 vs. 91짹30, p<0.001) were lower in multivessel group. In multivariate logistic regression analysis detecting independent predictors of multivessel CAD, older age and higher glycoalbumin were significant predictor of multivessel CAD. CONCLUSIONS: Increased glycoalbumin is associated with multivessel CAD, and may useful for pedicting multivessel CAD like other major risk factors.