Introduction
Coronary Percent atheroma volume (PAV) using intravascular ultrasound (IVUS) is very useful marker that is able to show minute progression or regression of atherosclerosis of coronary artery. But it is an invasive procedure that possesses potential hazard to patient. As an altenative, we suggest to perform radial artery IVUS rather than coronary IVUS for that purpose. To evaluated Radial artery PAV as a surrogate marker for atherosclerosis, we compared it with other ordinary surrogate markers for atherosclerosis.
Method
We performed radial IVUS and measured atheroma volume in 115 successive subjects who were undergoing transradial coronary angiogram due to chest pain, between February 2010 and March 2010. Most of the patient enrolled for study performed both carotid intima-media thickness measurement, and pulse wave velocity measurement within 1 month before or after radial IVUS measurement. We tested correlation between above 3 atherosclerosis markers, and compared measurements between patient with or without coronary artery disease. To evaluated risk of each maker for coronary artery disease(>70% stenosis of major branch) and risk for coronary intervention we performed Logistic regression.
Result
There was no complication associated with radial IVUS exam during this study.
PAV is significantly higher in coronary artery group while carotid IMT and ba-PWV failed to show significant difference. PVA showed modest relationship between ba-PWV(r=0.431 p<0.01) and c-IMT(r=0.443 , P<0.01). Radial PAV predict significant coronary artery atherosclerosis (p= )in logistic regression model containing PAV, cIMT, baPWV, LDL-cholesterol, HDL-cholesterol, Hs-CRP.
Conclusion
Radial artery IVUS PAV had moderate correlation with other atherosclerosis surrogates as IMT and baPWV. And It seemed to have association with coronary artery disease to a certain degree. Further evaluation including direct comparison with coronary PAV and radial PAV may be necessary.
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