Backgrounds: Percutaneous coronary intervention (PCI) of stenosis involving aorto-ostial lesions of coronary arteries is technically demanding. The aim of this study is to evaluate long-term clinical outcomes of patients with drug-eluting stents (DES) for the treatment of aorto-ostial coronary lesions. Materials and Methods: From 2005 to 2009, a total of 77 consecutive patients with 77 lesions underwent PCI with DES for aorto-ostial lesions, which consisted of right coronary artery ostium, 59 lesions and left main coronary artery ostium, 18 lesions. Study endpoints were major adverse cardiac events (MACE), including cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR) and stent thrombosis (ST) for 2 years after index PCI. Results: The procedure was successful in all the patients. Used stents were all drug-eluting stent and there were 37 sirolimus-eluting stents (48.1%), 32 paclitaxel-eluting stents (41.6%), 5 zotarolimus-eluting stents (6.5%) and 1 everolimus-eluting stent (3.9%). In-hospital mortality rate was 1.3%. One patient died of cardiogenic shock after PCI during hospitalization. Angiographic follow up at 9 months was performed on 37 patients (48%) and the restenosis rate was 10.8% (4/37). There were two focal body type, one focal proximal edge type and focal distal edge type was observed at angiographic follow-up. Mean follow-up duration was 682.5짹140.7 days. There were no MI for 2 years. TLR, TVR and late ST were 2.6%, 5.2% and 3.9%, respectively. Cardiac death was 7.8% for 2 years. Cumulative 2 year MACE-free survival was 87%. Conclusion: Long-term clinical outcomes of DES in patients with aorto-ostial lesions are favorable. Further large clinical trials are warranted. Key Words : Aorto-Ostial lesion, Percutaneous coronary intervention, long-term outcomes