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The Signal-Averaged P-Wave duration as a prognostic marker of Pulmonary Vein Isolation for the Treatment of Atrial Fibrillation
영남대학교 병원 순환기내과
김유민, 신동구, 강상욱, 박원종, 강민규, 이상희, 김웅, 홍그루, 박종선, 김영조
Background The aim of this study is to evaluate the usefulness of P-Wave Signal-Averaged Electrocardiogram (P-SAECG) in predicting the recurrence of Atrial Fibrillation (AF) after successful pulmonary vein isolation(PVI). Materials and Methods From Feb 2009 to March 2011, 32 drug-refractory AF patients who underwent PVI at our institute were enrolled (paroxysmal AF=23; 8, persistent AF) retrospectively. AF recurrence was defined as any atrial tachyarrhythmia documented during follow-up period, except first 3months after the PVI. The patients were divided into group 1 with recurrence (n=11) and group 2 without it (n=21). A P-SAECG was recorded at 1-day after PVI and followed up at 3-months. We analyzed P-SAECG parameters such as filtered and unfiltered P-wave duration, value of root-mean square voltage (terminal in 20, 30, and 40 ms, respectively), P-wave area and signal averaged P-wave morphology on 3 axes. The signal averaged P-wave morphology was divided into typical and atypical types. Baseline characteristics and echocardiographic findings were analyzed, too. Results Baseline characteristics showed no differences between 2 groups. Among the analyzed parameters on P-SAECG, initial filtered P-wave duration was longer in group 1 ( 156.36±51 Group 1 vs. 133.20±13.43, p=0.002 ). On multivariate analysis, initial FPD >130 ms (p=0.045, HR 4.056, C.I. 1.031 to 15.45) and atypical P wave morphology (p=0.043, HR 4.272, C.I. 1.044 to 17.39), Left atrial volume index >30ml/m2 (p=0.036, HR 6.597, C.I. 1.134 to 38.35) were a prognostic predictors for recurrence, but persistent AF, the left atrial dimension were not predictors for recurrence. Conclusions The Signal-Averaged P-Wave duration might be prognostic marker for recurrence of AF with successful PVI. More large clinical study will be needed. Key Words : Atrial fibrillation, Signal-Averaged P-Wave, Pulmonary vein isolation


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