Background: Recently it has been reported chemotherapeutic agent, adriamycin influences on not only the myocardium but the arteries. The aim of our study was to elucidate whether angiotensin receptor blocker, candesartan can improve adriamycin-induced aortopathy. Methods: Twenty four six-week old male Wistar-Kyoto rats were divided into four groups; control, adriamycin-treated (AD), candesartan-treated (C), and adriamycin and candesartan-treated (AD+C) groups. For AD groups, 2.5 mg/kg was administrated intraperitoneally of 6 equal injections for 3 weeks and for C groups, 0.5 mg/kg/day of candesartan was administrated orally. At sixth week, rats were sacrificed and the aortas were harvested. Verhoff���s elastic and Goldner���s trichrome stain were performed for histologic analyses. Tunica media thickness, parallel lamellar units of elastin, collagen and elastic tissue were measured quantitatively with Image-Pro Plus. Results: 1. Collagen/elastin ratio in AD group was higher than that in control group (1.6 짹 0.6 and 0.5 짹 0.2, respectively, p = 0.040). Collagen/elastin ratio in AD+C group was lower than that in AD group (1.1 짹 0.3 and 1.6 짹 0.6, respectively, p = 0.047; figure). 2. There were no significant differences of tunica media thickness and parallel lamellar units of elastin between four groups (p = 0.642 and 0.812, respectively). Conclusions: Candesartan can improve adriamycin-induced aortopathy.