Background: Few datas are available in the association of triglyceride (TG) level and cardiovascular risk factors in patients with controlled plasma low-density lipoprotein (LDL) cholesterol less than 100 mg/dL. The aim of study was whether hypertriglyceridemia is associated with major cardiac adverse events (MACE), including all-cause death, stroke, nonfatal myocardial infarction and revascularization of any cause in patients with controlled LDL cholesterol level, who underwent percutaneous coronary intervention (PCI) in drug eluting stent (DES) era.
Methods: Between January 2004 and December 2009, a total of 9,292 consecutive patients who underwent PCI with DES were enrolled. Among those, we analyzed 2,704 patients who had been kept on statin after PCI and whose LDL-C less than 100 mg/dL (median follow-up duration is 849 days). Cox proportional hazard analysis was used to analyze MACE in terms of variables including follow-up TG level over 200 mg/dL.
Results: After adjusting multiple variables, Multivariate Cox proportional hazard analysis revealed that multivessel disease and the presence of coronary angiographic ACC/AHA B2C lesion were associated with increased hazard ratios (HR). (HR=1.491, 95% CI 1.279–1.739, HR=1.227, 95% CI 1.027–1.466, respectively). However, follow-up TG level over 200mg/dL was not statistically significant in terms of MACE (HR=1.039, 95% CI 0.861–1.268).
Conclusions: In conclusion, plasma TG level was not closely associated with MACEs in patients with well controlled LDL-C level under 100 mg/dL who underwent PCI with DES. However, due to small study sample in this study, this result may not be conclusive.
Keywords: triglyceride, low-density lipoprotein cholesterol, percutaneous coronary Intervention

	Unadjusted HR	95% CI	p-value	Adjusted HR	95% CI	p-value
Multivessel disease	1.555	1.356-1.783	< 0.001	1.491	1.279-1.739	<0.001
B2C lesion	1.355	1.162-1.587	< 0.001	1.227	1.027-1.466	0.024
Follow-up TG ��� 200 mg/dL	1.066	0.894-1.272	0.475	1.039	0.861-1.268	0.706