Background: Transplanted hearts (TXH) show gradual irreversible decline in left ventricular (LV) compliance leading to chronic changes in diastolic function, while global LV ejection fraction (EF) remains preserved. Infiltrative cardiomyopathy such as amyloidosis affects on cardiac muscle also showed cardiac dysfunction mainly in diastolic phase. The aim of this study was to evaluate peculiar pattern of LV mechanics change in TXH and amyloid heart by comparison of normal subject. Methods: Total 74 subjects including 19 healthy controls (46짹18 yrs, 9 male), 17 patients with infiltrative cardiomyopathy (62짹9 yrs, 8 male) and 38 patients with cardiac transplantation (57짹9 yrs, 26 male) were evaluated. LV strains in longitudinal (LS), radial (RS) and circumferential (CS) directions were analyzed as well as rotational degree using commercial soft ware. One way ANOVA with Scheffe���s post Hoc test was used to compare strain value among 3 groups. Results: The longitudinal strain of TXH and amyloid heart was significantly lower than normal heart. (-13.5짹3.4 vs. –12.0짹4.0 vs. –18.5짹2.6%. P<0.001 vs. normal heart). The circumferential strain was significantly lower in TXH than normal heart (-10.8짹3.7 vs. –14.0짹4.5% for cardiac base, P=0.019, -14.9짹7.4 vs. –25.8짹10.0 for apex, P<0.001). The peak systolic rotational degree of apex was significantly lower in THX than amyloid or normal heart (6.3짹4.7 vs. 14.1짹10.0 vs. 15.2짹6.8 degree, P=0.001 vs. amyloid heart or normal heart). Conclusions: Decrease of longitudinal strain is the common mechanism of LV dysfunction in diseased heart. Decrease of apical rotational movement might be peculiar dysfunction of transplanted heart.