Objective ; Carotid plaque is used to predict future coronary vascular events, therefore detection of carotid plaque by use of ultrasound is used as a surrogate marker for coronary artery disease (CAD). The aim of this study is to evaluate the relations between serum lipoprotein level, apoliporptein, their ratios and the development of carotid plaque. Material and methods ; We excluded previous CAD, cerebrovascular disease, peripheral artery disease patients and patients who took lipid lowering drugs. 455 patients were divided into two groups. Group 1 (n=208) did not have carotid artery plaque by use of ultrasound and group 2 (n=247) had carotid plaque. Blood sample was collected from each subject after 12 hour fast. We checked serum lipoprotein and apolipoprotein A1, B. Results ; The subjects in the two groups were mainly man (56.7% vs 52.6%) with high portion of hypertension (58.1% vs 57.0%) and diabetes (30.0% vs 51.5%). HbA1c (6.9짹1.6mg/dL vs 7.2짹1.6mg/dL, p=0.20), LDL-c (116.7짹28.6mg/dL vs 116.5짹14mg/dL, p=0.63), HDL-c (49.3짹14.6mg/dL vs 47.8짹14.2mg/dL, p=0.29), Total cholesterol/HDL-c, Total cholesterol/HDL-c, LDL-c/HDL-c, hsCRP, body mass index were not significantly defferent between two groups. Age (53.8짹12.9 vs 64.4짹12.1, p=0.00), diabetes, smoking, apolipoprotein A1 (137.7짹26.7mg/dL vs 126.9짹27.4mg/dL, p=0.01) were significantly different. Carotid plaque incidence of high HDL subgroup (��� 60mg/dL) was not different compared with normal group. Conclusion ; Conventional major risk factors (age, diabetes, smoking) are important predictor for carotid plaque. Apolipoprotein A1 may be good predictor for relatively old patients with diabetes and relatively well controlled LDL-c.