Background: There are few studies comparing the clinical outcomes of left anterior descending artery lesion (LAD) and non-left anterior descending artery (Non-LAD) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods: A total of 685 patients with AMI undergoing PCI with DESs between 2004 to 2010 were enrolled (non-LAD, n=300 versus LAD, n=385). 1-year clinical outcomes including major adverse cardiac event (MACE), myocardial infarction, target vessel revascularization (TVR), target lesion revascularization (TLR), TVR-MACE, TLR-MACE were compared between two groups. Results: There were no significant differences between the two groups except LAD group had more male, more history of current smoking and diabetes, lower left ventricular ejection fraction (LVEF), longer stent length, higher number of implanted stents (table). In-hospital cardiac death was similar to two groups. At 12 clinical outcomes (follow-up rate:92.4%), acute myocardial infarction was higher in LAD group. However, when adjusted by gender, diabetes, current smoking, LVEF, and stent length, clinical outcomes were not significantly different in two groups (table). Conclusions: The AMI of LAD artery doesn���t seem to be different in a adverse clinical outcomes up to 12 months, compared with non-LAD artery.