Background: Unprotected left main (LM) bifurcation angioplasty with drug-eluting stent (DES) is being performed by two major stenting technique (kissing or crushing stenting) but the safety and efficacy of two different techniques are not fully elucidated yet. Methods: All patients (pts) with unprotected LM bifurcation lesion electively treated with sirolimus-(SES; Cypher), paclitaxel (PES; Taxus), everolimus (EES; Xience or Promus), or zotarolimus (ZES; Endeavor)-eluting stent by one or two stenting strategy were enrolled. LM true bifurcation lesions were treated by two stenting, crushing or kissing technique from 2004 to 2010. This study is to assess whether the different two stenting strategies either by Crushing or Kissing would have similar angiographic and clinical outcomes up to 12 months. Results: Out of total 183 pts (Male 129, mean age, 64.48짹10.69 years) who underwent standard percutaneous coronary intervention (PCI) with DES in unprotected LM lesion. A total 44 pts who had true LM bifurcation lesion (26/131, 24.0 %) were treated with two stenting (crushing and kissing). DES type was not different between the two groups. At 6 to 9 months, angiographic outcomes were similar between the two groups. Also, there were no significant differences in major clinical outcomes between the two groups up to 12 months (Table). Conclusions: Crushing and kissing stenting appears to be similarly effective stenting strategy in treating LM true bifurcation lesion up to 12 months. Further updated data with larger study population will be needed to get the final conclusion.