Background: Left ventricular hypertrophy (LVH) is known for an important marker of cardiovascular disease. ASE committee changed traditional cut-off points to define LVH at 2005 because traditional criterias might overlook cardiovascular risk in the normal group. We previously described prevalence and clinical characteristics in newly diagnosed LVH group by applying the new cut-off points. In the present study, we sought to evaluate whether new cut-off points influence prevalence of cardiovascular events or not.
Methods: A retrospective analysis was conducted of 5202 consecutive patients who performed echocardiography in our center. First, we compared clinical outcomes between 2200 LVH group included 773 new LVH patients (group 1), 1427 traditional LVH patients (group 2) and 3002 non-LVH group (group 3) from January 2007 to August 2010. Second, we looked for the effect of lowering cut-off value of LVH on the cardiovascular events.
Results: There was higher incidence of CHF, CVA, hospitalization and death in group 1 and 2 than group 3 as expected. In subgroup analysis, group 1 patients had significant lower incidence of CHF, CVA among cardiovascular risks compared with group 2 patients. (p<0.05) On the other hand, only hospitalization had higher tendency in group 1 than group 2 (relative risk: 1.234, p= 0.055). However when we compared with group 3, group 1 patients had much more prevalent major adverse cardiac events (MACE) except MI with statistical significance. (Table 1)
Conclusions: Applying new LVH classification criteria, the incidence of MACE in LVH patients has increased in Korean. Although additional new LVH group (group 1) was insufficient to predict MACE than traditional LVH group (group 2), lowering cut-off value of LVH was effective to predict cardiac events.
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