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Prevalence of adverse cardiac events in left ventricular hypertrophy (LVH) patients by new ASE-guidelines in Korean
순천향 대학교 부속 부천병원 심장내과
하태훈, 서혜선, 최재혁, 서존, 조윤행, 이내희
Background: Left ventricular hypertrophy (LVH) is known for an important marker of cardiovascular disease. ASE committee changed traditional cut-off points to define LVH at 2005 because traditional criterias might overlook cardiovascular risk in the normal group. We previously described prevalence and clinical characteristics in newly diagnosed LVH group by applying the new cut-off points. In the present study, we sought to evaluate whether new cut-off points influence prevalence of cardiovascular events or not. Methods: A retrospective analysis was conducted of 5202 consecutive patients who performed echocardiography in our center. First, we compared clinical outcomes between 2200 LVH group included 773 new LVH patients (group 1), 1427 traditional LVH patients (group 2) and 3002 non-LVH group (group 3) from January 2007 to August 2010. Second, we looked for the effect of lowering cut-off value of LVH on the cardiovascular events. Results: There was higher incidence of CHF, CVA, hospitalization and death in group 1 and 2 than group 3 as expected. In subgroup analysis, group 1 patients had significant lower incidence of CHF, CVA among cardiovascular risks compared with group 2 patients. (p<0.05) On the other hand, only hospitalization had higher tendency in group 1 than group 2 (relative risk: 1.234, p= 0.055). However when we compared with group 3, group 1 patients had much more prevalent major adverse cardiac events (MACE) except MI with statistical significance. (Table 1) Conclusions: Applying new LVH classification criteria, the incidence of MACE in LVH patients has increased in Korean. Although additional new LVH group (group 1) was insufficient to predict MACE than traditional LVH group (group 2), lowering cut-off value of LVH was effective to predict cardiac events.

 

 

Additional LVH by new criteria (group 1)

Non-LVH

(group 3)

Odds Ratio

P-value

CHF

27/773

(3.5%)

38/3002

(1.3%)

2.692

<0.001

CVA

105/773

(13.6%)

314/3002

(10.5%)

1.295

0.014

Hospitalization

122/773

(15.8%)

354/3002

(11.8%)

1.339

0.003

Death

6/773

(0.8%)

7/3002

(0.2%)

4.000

0.022

MI

60/773

(7.8%)

190/3002

(6.3%)

1.245

0.153



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