Aims: The definition of contrast induced acute kidney injury (CIAKI) is elevation of serum creatinine level within 48-72hours after applying contrast medium. Coronary angiography is essential procedure for assessing and treatment of coronary artery disease (CAD), because the prevalence of CAD is higher than general population. CIAKI is 3rd common cause of acute renal failure (ARF) in hospital patients. RAAS blockade agent is one of most common medication of CAD. The effect of RAAS blockade agent on CIAKI has not clarified yet, therefore we tried to find out the effect of RAAS blockade on CIAKI after coronary angiography. Methods: We reviewed charts of patient performed coronary angiography in our hospital(May 2009-July 2011). We recorded serum creatinine levels before and after coronary angiography. The criteria of CIAKI were serum creatinine elevation of more than 0.05mg/dl or more than 25% compared to baseline. Results: The groups of Patient with RAAS blockade agent (RAAS(+)) and without (RAAS(-)) were total 456 and 1179 case, respectively. The ratio of CIAKI presence after coronary angiography was significantly different between RAAS (+) and RAAS(-) groups in total case. In sub-group analysis, the groups of Patient with RAAS blockade agent (RAAS(+)) and without (RAAS(-)) were total 247 and 200 case in DM case, respectively. The groups of Patient with RAAS blockade agent (RAAS(+)) and without (RAAS(-)) were total 256 and 932 case in non-DM case, respectively. The ratio of CIAKI presence after coronary angiography was significantly higher in RAAS(+) group than RAAS(-) in non-DM patient. However, in DM group the ratio of CIAKI presence after coronary angiography was significantly different between RAAS (+) and RAAS(-) groups. Conclusions: Using RAAS blockade agents before coronary angiography increase the onset of CIAKI compared to not using that medications except in non-DM patients, but not increased in Diabetes.