Background:Diabetes mellitus (DM) is known to be a strong risk factor of cardiovascular disease. However, there were limited data about the impact of DM on diastolic dysfunction. The aim of this study is to evaluate the influence of DM on diastolic dysfunction in patients (pts) with non ischemic left ventricular systolic dysfunction.Methods:A total of 182 consecutive pts who had non ischemic left systolic dysfunction were enrolled from May 2004 to June 2010. The pts with acute myocardial infaction, moderate to severe valvular dysfunction, chronic renal insuffiency were excluded. The patients were divided into two groups according to existence of DM (DM group: n=76, non DM group:n=106). Baseline clinical and echocardiographic characteristics were compared between two groups.Results: Baseline clinical characteristics showed that the incidence of hypertension (65.8% vs 34.9%, p<0.001) and hyperlipidemia (28.9% vs 12.3%, p=0.007) were higher in DM group compared with non DM group. Baseline echocardiographic characteristics showed that there were nodifference of systolic function including left ventricular ejection fraction (LVEF) and left ventricular mass index. Doppler echocardiographic data showed that E/E��� (20.31짹10.02 vs 16.58짹8.23, p=0.022) and E��� (0.037짹 0.013 vs 0.046 짹 0.019, p=0.002) were higher in DM group compared with non DM group. Multivariate analysis showed that DM was not independent risk factor of diastolic dysfunction (E/E���>15). Conclusions: In this study, DM is associated with hypertension and hyperlipidemia and diastolic dysfunction including E/E��� and E��� in pts with non ischemic left systolic dysfunction. However, DM was not an independent risk factor of diastolic dysfunction (E/E���>15).