Objectives: We aimed to compare long-term outcomes of a modified mini-crush technique with classic crush technique for treating bifurcation lesions. Background: Modified mini-crush technique showed excellent technical and angiographic success immediately and it also provides acceptable 9 months clinical outcomes. We assessed and compared 2 year clinical outcomes of modified mini-crush technique with classic crush technique. Methods: We enrolled 173 patients treated with modified mini-crush (n=107) and classic crush technique (n=66) in our registry. The modified mini-crush technique is performed to minimize crushing, the proximal marker of the side branch (SB) stent was located in contact with the main vessel (MV) stent. After SB stenting, we drew the SB balloon proximally and dilate the SB ostium at a rated burst pressure. After MV stenting, both vessels were redilated at a high pressure before final kissing balloon inflation. Clinical and angiographic follow-up data were obtained after 2 years. Results: Mean age was 60 years old, and left main bifurcation lesion was 26% in classic crush and 22 % in modified mini-crush group. We assessed the major adverse cardiac events (MACE); All-cause death, myocardial infarction, target lesion revascularization (TLR) and stent thrombosis after 2 years. There was no significant difference in follow- up duration (934 vs. 950 days). After 2 years, the incidences of MACE are 19.7% in classic crush and 11.2% in modified mini-crush (p= 0.18). The incidence of all-cause death was 4.5 % vs. 4.7% (p=0.64), myocardial infarction was 3 % vs. 0.9 % (p=0.33), TLR was 15.2 % vs. 7.5 % (p=0.13) and stent thrombosis was 3 % vs. 0.9 % (p=0.33) in classic crush and modified mini-crush group, respectively. However, the rate of in-stent restenosis at bifurcation lesion was 36.9% in classic crush and 20.0 % in modified mini-crush group (p= 0.068) Conclusions: Modified mini-crush technique was showed similar and excellent long-term clinical outcome and had a favorable tendency in angiographic outcomes comparing with classic crush technique.