BACKGROUND: Prediction of cardiovascular risk in healthy individual is challenging and there is a diurnal variation of blood pressure on target organ damage. The aim of this study is to determine the individual effect of abnormalities in blood pressure (BP) circadian rhythm on target organ damage (TOD) and which of these is more closely related to TOD in patient with hypertension. METHODS: The 24-h ambulatory BP monitoring (ABPM) and echocardiography and urinary microalbumin/creatinin ratio were measured in 115 dipper, 118 non-dipper and 60 reverse dipper subjects. RESULTS: Decline in sleep BP (%) is reverse correlation with left ventricular mass index(r=0.18, p<0.01)(left side of figure). The left ventricular mass index was higher in reverse-dipper group (143.6짹35.5 vs 131.4짹33.3 g/m2, P=0.03) than dipper group(right side of figure). Urine microalbumin/creatinin ratio was no significant difference among three group (0.11짹0.22 vs 0.12짹0.34 vs 0.09짹0.16, p=0.73, dipper vs non-dipper vs reverse dipper respectively). CONCLUSIONS: It may be postulated that increased night BP are the factors that cause left ventricular hypertrophy,so reverse dipper in ABP is related to increased left ventricular mass index. and it seems reasonable to attempt to restore normal circadian rhythm of the BP even in patients with hypertension.