Background and Objectives: Transradial approach has become a popuplar route for percutaneous coronary intervention (PCI). But, PCI of bifurcation lesion is still challenging. We assessed the clinical outcome between transradial intervention (TRI) and transfemoral intervention (TFI) in coronary bifurcation lesion. Subjects and Methods: The study population was derived from TRI working group retrospective registry from 16 institutes in Korea between January 2009 and December 2009. Exclusion criteria were patient with Killip class IV, patient with cardiogenic shock and patient with serum creatinine>3.0mg/dL. A total of 937 patients with 1050 bifurcation lesions was assessed for this study. Major adverse cardiovascular event (MACE) was defined as the composites of death, myocardial infarction, target lesion revascularization, target vessel revascularization and stent thrombosis. Results: Mean age was 65.1짹10.9 years and male was 628 patients (67%). The rate of acute coronary syndrome was not different between TRI and TFI group (78.3% vs. 74.2%, p=0.158). There was no difference in lesion distribution. The time of total procedure was longer in TRI group (49.8짹28.3 mins vs. 45.7짹30.2 mins, p=0.048) and the rate of crossover was higher in TRI group (0% vs. 3.6%, p<0.001). But TRI group showed significant shorter duration of hospitalization (4.0짹3.9 days vs. 6.3짹8.3 days, p<0.001) and lower rate of bleeding complication associated with PCI (3.1% vs. 6.7%, p=0.017). MACE was no difference between TRI group (n=53, 13.8%) and TFI group (n=60, 10.8%) (p=0.185). Conclusions: TRI reduced duration of hospitalization and bleeding complication and showed no difference of MACE. Therefore, transradial approach can be a feasible route for bifurcation lesion.