Objectives: This study was designed to investigate the prevalence of depression in adults with congenital heart disease(CHD) and identify factors influencing the depression. Methods: The Center for Epidemiologic Studies-depression scale was administered in order to evaluate depression levels among 216 adults with CHD from a major cardiac center. This group consisted of 105 males and 111 females. The average age was 42.7 years(range: 18-68 years). Cardiac disease severity was operationalized in terms of initial diagnosis (classification of ���Task force 1��� of the 32nd Bethesda conference), illness course(Disease severity index) and current functional status(NYHA class, ability index, congenital heart disease functional index, percutaneous oxygen saturation and plasma NT-proBNP). Data were analyzed using descriptive statistics, pearson correlation and multiple logistic regression with SPSS 19.0. Results: The average depression score of the subjects was 18.76, which indicates moderate levels of depression. About 33% of subjects in this study reported moderate or severe levels of depression. Significant predictors of depression were young age(OR=2.12, P<0.001), female(OR=1.89, P=0.012), worse NYHA class(OR=1.26, P=0.023), worse ability index(OR=0.69, P=0.017) and higher congenital functional index(OR=1.03, P=0.001), lower oxygen saturation(OR=1.56, P=0.023) and higher NT proBNP(OR=2.93, P<0.001). Conclusions: The findings of this study suggested that younger females with worse functional class require concern regarding the risk of developing depression. Regular depression screening and observing of NT-proBNP could be beneficial for early detection of depression in adults with CHD.