Background: Recently, several case reports suggested that stress-induced cardiomyopathy (SCMP) reveals various morphologic features of left ventricle (LV). However, there is paucity of data dealing with the clinical characteristics and presentations among these patients. Objectives: Therefore, we investigated the morphologic features of LV in SCMP patients, and differentiate their clinical characteristics and presentations. Moreover, we evaluated which factor can be the predictor for adverse outcome in SCMP patients. Methods: This was a multi-center, retrospective study. We enrolled 234 patients from 1998 to 2010. Morphologic features of LV was determined by echocardiography and categorized as 1) apical ballooning, 2) mid-LV ballooning, 3) reverse, 4) apical-tip sparing, 5) global hypokinesis, and 6) unclassified type. Results: Among 234 patients, apical ballooning type showed preponderance (59.4%) of SCMP followed by mid-LV ballooning type (24.4%), unclassified type (6.8%), apical-tip sparing type (4.3%), reverse type (2.6%), and global hypokinesis type (2.6%), respectively. Patients with typical SCMP were older (68.4짹13.0 vs. 61.5짹14.2 years, p<0.0001) and hypertensive (61.9% vs. 38.9%, p=0.001). In addition, patients with typical SCMP tend to have ST-segment elevation at initial ECG (p=0.030). However, there was no differences in triggering events (p=0.285), clinical presentations, and in-hospital mortality(8.1% vs. 8.5%, p=0.909) between patients with typical and atypical SCMP. When determining the independent predictor for in-hospital mortality in SCMP patients, multivariate analysis revealed that age, shock, coronary artery disease (CAD), and left ventricular ejection fraction (LVEF) were the independent risk factors (Table 1). Conclusions: SCMP not only presents various clinical, electrocardiographic, angiographic, and echocardiographic characteristics, but also demonstrates diverse morphologic spectrum of LV. Therefore, it is necessary that we should pay more attention when undergoing differential diagnosis for patients with acute coronary syndrome. In addition, physical stressors, age, hemodynamic compromise, existence of CAD, and initial LVEF are independent risk factors that may predict worse outcome.