Background: Serum uric acid (UA) and serum glycosylated hemoglobin (HbA1c) are considered as important roles in the development and progression of hypertension. We investigated the correlations of UA levels and HbA1c levels and indices of arterial function in healthy, newly diagnosed, never-treated hypertensive patients without diabetes mellitus. Methods: 143 patients with new diagnosis of arterial hypertension for which they had never received treatment and did not have diabetes mellitus were enrolled in the study (mean age 51 years, 52.3% men, mean BMI 24.77, mean SBP: 147mmHg, mean DBP: 89mmHg, mean HR: 68/min). Serum UA, serum HbA1c, and augmentation index (AIx) of aortic pressure were measured. Results: Mean central BP is 87.89짹14.20mmHg (SBP: 114.35mmHg짹16.73mmHg, DBP: 74.60짹14.31, AIx: 28.81짹10.05). There was positive correlation between serum HbA1c levels and AIx of aortic pressure (R=0.337, P=0.000). In other hands, there was negative correlation between UA and AIx of aortic pressure (R=0.415, P=0.000). Conclusions: In our study, serum HbA1c level is a positive correlation with Aix of peripheral and aortic pressure. However, UA is a negative correlation with Aix of peripheral and aortic pressure in comparison with other studies, reported that UA is a positive correlation with Aix of peripheral and aortic pressure.