Background: Extracorporeal membrane oxygenation (ECMO) has been indicated as treatment for acute cardiac and/or respiratory failure. Pulse pressure, as a marker for cardiac function, is easy to obtain in bedside. We analyze our cases in order to determine the role of pulse pressure as a predictive marker for survival in patients with ECMO. Methods: From January 2009 to August 2011, 69 patients were reviewed who were supported by ECMO due to cardiac and/or respiratory failure. We compared mean pulse pressure during first 6 hours after ECMO support between survival and non survival group. We analyze prognostic significance of mean pulse pressure for in-hospital mortality (survival and discharge). Results: Mean age was 57.7 짹 16.2 and cardiac disease was 35 (50.7%) patients. 15 (21.7%) patients survived and discharged. Mean pulse pressure was significantly high in survival group as compare with non survival group (37.9 짹 9.6, 28.1 짹 16.1, respectively, P=0.027) . Mean pulse pressure was a significant prognostic factor for survival (unadjusted hazard ratio [HR]: 0.95; 95% confidence interval [CI]: 0.91 to 0.99, P=0.034) . Among the other hemodynamic parameters, pre-ECMO systolic blood pressure (SBP) was significant prognostic factor (HR: 0.98, 95% CI: 0.97 to 0.99, P=0.030) . However, post-ECMO SBP and ejection fraction (EF) were not significant (HR: 0.98, 95% CI: 0.97 to 0.10, P=0.105; HR: 0.98, 95% CI: 0.95 to 1.01, P=0.367, respectively). In multivariate analysis, pulse pressure adjusted by pre-ECMO SBP, pulse pressure was a significant prognostic factor for survival (HR: 0.95, 95% CI: 0.91 to 0.99, P=0.045). Conclusion: Pulse pressure could be used as an easy tool on bedside to predict survival in patients with ECMO.