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ȣ - 550948 87 |
Comparison of magnetic resonance imaging findings in non-ST-segment elevation versus ST-segment elevation myocardial infarction patients undergoing early invasive intervention |
성균관대의대 삼성서울병원 |
송영빈, 한주용, 권현철, 장성아, 이상철, 최연현, 최승혁, 최진호, 이상훈, 오재건 |
To define causes and pathological mechanisms underlying differences in clinical outcomes, we compared the findings of contrast-enhanced magnetic resonance imaging (CE-MRI) between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). In 168 patients undergoing early invasive intervention for STEMI (n=113) and NSTEMI (n=55), CE-MRI was performed a median of 6 days after the index event. Infarct size was measured on delayed-enhancement imaging, and area at risk (AAR) was quantified on T2-weighted images. The median infarct size was significantly smaller in the NSTEMI group than in the STEMI group (10.7% [5.6-18.1] versus 19.2% [10.3-30.7], P<0.001). Although there was a trend toward a greater myocardial salvage index ([AAR - infarct size] × 100/ AAR) in the NSTEMI group compared to the STEMI group (48.2 [30.4-66.8] versus 40.5 [24.8-53.5], P=0.056), myocardial salvage index was similar between the groups in patients with anterior infarction (39.6 [20.0-54.9] versus 35.5 [23.2-53.4], P=0.96). The NSTEMI group also had a significantly lower extent of microvascular obstruction and a smaller number of segments with >75% of infarct transmurality relative to the STEMI group (0% [0-0.6] versus 0.9% [0-2.3], p<0.001 and 3.0±2.3 versus 4.6±2.9, P=0.001, respectively). Myocardial hemorrhage was detected less frequently in the NSTEMI group than the STEMI group (22.6% versus 43.8%, P=0.029). In the multivariate analysis, baseline Thrombolysis In Myocardial Infarction flow grade 3 and hemorrhagic infarction were closely associated with ST-segment elevation (OR 0.32, 95% CI 0.13-0.81, P=0.017; OR 5.66, 95% CI 1.77-18.12, P=0.003, respectively). In conclusion, in vivo pathophysiological differences revealed by CE-MRI assessment include more favorable infarct size, AAR, myocardial salvage and reperfusion injury in patients with NSTEMI compared to those with STEMI undergoing early invasive intervention.
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Variables |
NSTEMI
(n=55) |
STEMI
(n=113) |
P value |
LVEDV, mL |
134.7 (108.0-156.5) |
135.8 (112.8-157.1) |
0.402 |
LVESV, mL |
56.9 (41.5-73.8) |
67.0 (47.5-85.7) |
0.023 |
LV ejection fraction, % |
55.4 (47.2-64.9) |
49.4 (40.4-58.2) |
0.004 |
Infarct size, % of LV |
10.7 (5.6-18.1) |
19.2 (10.3-30.7) |
< 0.001 |
Area at risk, % of LV |
20.6 (15.2-29.5) |
32.9 (22.7-45.9) |
< 0.001 |
Myocardial salvage index |
48.2 (30.4-66.8) |
40.5 (24.8-53.5) |
0.056 |
Microvascular obstruction area, % of LV |
0 (0-0.6) |
0.9 (0-2.3) |
< 0.001 |
Transmural infarct segments counts |
3.0 ± 2.3 |
4.6 ± 2.9 |
0.001 |
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