Background ; Exertional hypertensive response (Ex-HTN), is a poor prognostic indicator for cardiovascular mortality. Here we tried to investigate the effect of Ex-HTN on vascular physiology in non-hypertensives.
Methods ; A total of 54 patients without hypertension was enrolled (mean age, 55.2 ± 10.6; male, 52.4%; mean blood pressure, 126.2 ± 12.6 mmHg in systolic and 76.6 ± 6.4 mmHg in diastolic) and 20 of normal control. Eighteen patients (33.3%) have diabetes. They were performed treadmill test and pulse wave velocity (PWV) for chest pain or dyspnea. Patients with severe coronary artery disease, left ventricular dysfunction or renal failure were excluded.
Results ; Peak systolic blood pressure, blood pressure change during exercise in group of Ex-HTN were higher than normal control. Indices of peripheral arterial stiffness (baPWV and faPWV) were more higher in group of Ex-HTN than normal control (baPWV, 1543.3 ± 160.9 vs 1356.1 ± 191.3 m/sec, p = 0.048; faPWV, 1176.0 ± 178.5 vs 1022.6 ± 137.7 m/sec, p = 0.033), but central aortic stiffness was not (hfPWV) (p = 0.091).
Conclusions ; Ex-HTN may be related with peripheral arterial stiffness rather than central aortic stiffness in non-hypertensives.
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