Backgroud The relationship of time rate of blood pressure (BP) variation to left ventricular (LV) systolic dyssynchrony have never explored. Methods 102 subjects with never-treated hypertension (age : 51.3 ± 13.2 years, male 53.9%) were enrolled and all underwent echocardiography and ambulatory BP monitoring. Standard deviation of time from ECG Q to systolic peak velocity of 12 LV segments (ms, Ts-SD12) and maximum difference of time to systolic peak velocity among 12 LV segments (ms, Ts-max) were calculated by echocariography. LV systolic dyssynchrony was defined as a Ts-SD12 ≥33ms or Ts-Max ≥100ms. The time rate of BP variation was defined as the first derivative of the BP values against time. Results The prevalence of LV systolic dyssynchrony was identified as 42.2% (43 of 102). Systolic BP at 24 hours and daytime and diastolic BP at 24 hours and daytime were associated with the presence of LV systolic dyssynchrony in both univariate and multivariate analysis. Conclusion The time rate of BP variation was independently associated with the presence of LV systolic dyssynchrony.
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Relationship of time rate of blood pressure variation to the presence of left ventricular systolic
dyssynchrony
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Univariate (OR, 95% CI) |
Multivariate (OR, 95% CI) |
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Time rate of BP variation |
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SBP (24 hours) |
95.4 (3.3-2779.2)* |
135.0 (2.3-7774.7)* |
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SBP (daytime) |
50.0 (2.5-989.1)* |
58.5 (1.5-2213.9)* |
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SBP (nighttime) |
7.4 (0.5-102.0) |
8.8 (0.4-204.8) |
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DBP (24 hours) |
101.2 (3.7-2748.8)* |
59.4 (1.2-3032.6)* |
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DBP (daytime) |
34.9 (2.5-492.4)* |
25.3 (1.0-630.0)* |
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DBP (nighttime) |
2.7 (0.2-42.5) |
1.9 (0.1-59.0) |
OR, odds ratio; CI, confidence interval; BP, blood pressure; SBP, systolic BP; DBP, diastolic BP. Multivariate analysis was adjusted for age, sex, fasting blood glucose, estimated glomerular filtration rate, hyperlipidemia, smoking status, left ventricular mass index, body mass index, high-sensitive C-reactive protein, and BP. * indicated P value < 0.05.
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